This ones my favorite list. The best villains in video games.
The list simplified
Spoiler
If you don't know a character, go on the link and click on the name.100. Mario
99. Coily
98. Gary Oak
97. Shang Tsung
96. Adrian Ripburger
95. Captain Onishima
94. Lance Vance
93. Singe
92. Sniper Wolf
91. Seifer
90. Dagoth Ur
89. Sander Cohen
88. Dark Samus/Sa-X
87. Officer Tenpenny
86. Jacqueline Natla
85. Sub Zero
84. Cronos
83. Death Adder
82. Purple Tentacle
81. Psy-Crow
80. Bydo
79. Jafar/Vizier
78. Evil Otto
77. Shadow Link/Dark Link
76. Red Falcon
75. Lavos
74. Diablo
73. Alma
72. Tom Nook
71. Dark Falz
70. Gruntilda
69. Cyberdemon
68. Calypso
67. Goro
66. Kane
65. Dr. Nefarious
64. King Hippo
63. Master-D
62. Carmen Sandiego
61. Predator
60. Prophet of Truth
59. Nemesis
58. Frank Fontaine
57. Origami Killer
56. Zombies
55. Ares
54. Captain Qwark
53. Liquid Snake
52. Magus
51. Tank
50. Team Rocket
49. Zeus
48. Geth
47. Shodan
46. Grue
45. Flood
44. Kessler
43. Akuma
42. Sinistar
41. Arthas
40. Sofia Lamb
39. Harbinger
38. Bob the Killer Goldfish
37. Lich King
36. Dormin
35. John Henry Eden
34. Kain
33. Darth Malak
32. Big Boss
31. Wario
30. Ultros
29. Saren
28. Revolver Ocelot
27. Dr. Breen
26. Covenant
25. Darth Vader
24. LeChunk
23. Dracula
22. Combine Soldiers
21. Mecha-Hitler
20. Joker
19. M. Bison
18. Kefka
17. Kerrigan
16. Space Invader
15. Great Mighty Poo
14. Albert Wesker
13. Dr. Wily
12. Mike Tyson
11. Dr. Robotnik
10. Andrew Ryan
9. Mother Brain
8. Psycho Mantis
7. Pac-Man Ghosts
6. Nazis
5. Donkey Kong
4. Sephiroth
3. Ganon/Ganondorf
2. Bowser
1. GlaDOS
99. Coily
98. Gary Oak
97. Shang Tsung
96. Adrian Ripburger
95. Captain Onishima
94. Lance Vance
93. Singe
92. Sniper Wolf
91. Seifer
90. Dagoth Ur
89. Sander Cohen
88. Dark Samus/Sa-X
87. Officer Tenpenny
86. Jacqueline Natla
85. Sub Zero
84. Cronos
83. Death Adder
82. Purple Tentacle
81. Psy-Crow
80. Bydo
79. Jafar/Vizier
78. Evil Otto
77. Shadow Link/Dark Link
76. Red Falcon
75. Lavos
74. Diablo
73. Alma
72. Tom Nook
71. Dark Falz
70. Gruntilda
69. Cyberdemon
68. Calypso
67. Goro
66. Kane
65. Dr. Nefarious
64. King Hippo
63. Master-D
62. Carmen Sandiego
61. Predator
60. Prophet of Truth
59. Nemesis
58. Frank Fontaine
57. Origami Killer
56. Zombies
55. Ares
54. Captain Qwark
53. Liquid Snake
52. Magus
51. Tank
50. Team Rocket
49. Zeus
48. Geth
47. Shodan
46. Grue
45. Flood
44. Kessler
43. Akuma
42. Sinistar
41. Arthas
40. Sofia Lamb
39. Harbinger
38. Bob the Killer Goldfish
37. Lich King
36. Dormin
35. John Henry Eden
34. Kain
33. Darth Malak
32. Big Boss
31. Wario
30. Ultros
29. Saren
28. Revolver Ocelot
27. Dr. Breen
26. Covenant
25. Darth Vader
24. LeChunk
23. Dracula
22. Combine Soldiers
21. Mecha-Hitler
20. Joker
19. M. Bison
18. Kefka
17. Kerrigan
16. Space Invader
15. Great Mighty Poo
14. Albert Wesker
13. Dr. Wily
12. Mike Tyson
11. Dr. Robotnik
10. Andrew Ryan
9. Mother Brain
8. Psycho Mantis
7. Pac-Man Ghosts
6. Nazis
5. Donkey Kong
4. Sephiroth
3. Ganon/Ganondorf
2. Bowser
1. GlaDOS