Warning - this requires some editing. You will need a hex editor program. (I used this one - http://www.chmaas.handshake.de/delphi/freeware/xvi32/xvi32.htm)
1. Make a backup copy of \Steam\steamapps\common\skyrim\Data\Skyrim - Interface.bsa, and then open the original with a hex editor. You should be able to see text/chars in the side window.
2. Scroll way, way down, to about address 34,701,270 (or search for "// Main Gameplay". You will see a bunch of text, that cleaned up, looks something like the code snippet below. The 1st column is the game event, the 2nd column refers to keyboard key ID's, the 3rd to Mouse button ID's, and the 4th to Gamepad button ID's. Notice that Hotkey 1 has keyboard key ID's of "0x02, 0x4f". After many hours of researching scan codes & hex unicodes, I know that this refers to "1" and "NumPad 1" respectively.
//Main GameplayForward 0x11 0xff 0xff 1 1 0 0x801Back 0x1f 0xff 0xff 1 1 0 0x801Strafe Left 0x1e 0xff 0xff 1 1 0 0x801Strafe Right 0x20 0xff 0xff 1 1 0 0x801Move 0xff 0xff 0x000b 0 0 0 0x801Look 0xff 0xa 0x000c 0 0 0 0x2Left attk/block 0xff 0x1 0x000a 1 1 1 0x841Right attk/block 0xff 0x0 0x000a 1 1 1 0x841Activate 0x12 0xff 0x1000 1 1 1 0x804Ready Weapon 0x13 0xff 0x4000 1 1 1 0x840Tween Menu 0x0f 0xff 0x2000 1 1 1 0x908Toggle POV 0x21 0xff 0x0080 1 1 1 0x820Zoom Out 0xff 0x9 0xff 0 0 0 0x220Zoom In 0xff 0x8 0xff 0 0 0 0x220Jump 0x39 0xff 0x8000 1 1 1 0xC01Sprint 0x38 0xff 0x0100 1 1 1 0x801Shout 0x2c 0xff 0x0200 1 1 1 0x840Sneak 0x1d 0xff 0x0040 1 1 1 0x881Run 0x2a 0xff 0xff 1 1 1 0x801Toggle Run 0x3a 0xff 0xff 1 1 0 0x801Auto-Move 0x2e 0xff 0xff 1 1 0 0x801Favorites 0x10 0xff 0x0001,0x0002 1 1 0 0x908Hotkey 1 0x02,0x4f 0xff 0x0004 0 0 0 0x908Hotkey 2 0x03,0x50 0xff 0x0008 0 0 0 0x908Hotkey 3 0x04,0x51 0xff 0xff 0 0 0 0x908Hotkey 4 0x05,0x4b 0xff 0xff 0 0 0 0x908Hotkey 5 0x06,0x4c 0xff 0xff 0 0 0 0x908Hotkey 6 0x07,0x4d 0xff 0xff 0 0 0 0x908Hotkey 7 0x08,0x47 0xff 0xff 0 0 0 0x908Hotkey 8 0x09,0x48 0xff 0xff 0 0 0 0x908
3. Edit out the 2nd part of every hotkey 2nd column entry. For example, change Hotkey 1 from "0x02,0x4f" to "0x02". (When I looked at the raw hex data for other entries, there were 4 "09" entries between the 2nd & 3rd data sets, so I made sure to keep the same when I edited these).
4. Save the file, and start Skyrim. You may now bind your numpad keys (just got back in game, and I now use Num5 for Forward, Num2 for Back, Num1 & 3 for strafing left/right).
I do not know what effect this will have on other key usage choices.
Enjoy!

Although, if you remove the 2nd set as I mention, the numpad 1-8 keys will no longer be reserved for the hotkeys.