I would stick back, shoot the enemy with a silenced sniper, then head towards the area I am attacking and use a silenced weapon to kill the ones that I would have missed...
I got ED-E and left him in my Novac motel room. I still have the perk so I see the red dots from a mile away. At which point I carefully move forward and take the enemies out with my Gauss Rifle. At close combat I use the Gauss Rifle in VATS to cripple the enemies legs while Raul blasts away at them with the Plasma Defender.