I want to know how much of the single player story we know now, or (reasonable) ideas for what is most likely the story going to be about.

I'm pretty sure I've heard somewhere that Alcatraz his disabled and uses the suit as somekind of augmentation, and the suit fails him somehow, like he can't get out of it.

I think there was a warning about the suit on the crynet promopage where it says that prolonged usage of the suit is dangerous due to its neural interfacing... or somethn like that

The world has been ravaged by a series of climatic disasters and society is on the verge of total breakdown. Now the aliens have returned, with a full invasion force bent on nothing less than the total annihilation of mankind, starting by trying to rip the heart out of Earth’s most iconic city: New York.

Just to survive will require technology beyond anything any modern soldier has ever seen. One man will inherit that means to survive. Wielding the combat enhancement technology of the future with Nanosuit 2, you alone will be the weapon that can make a last stand to save humanity from destruction in the urban jungle that is New York City.
http://www.sosnewyork.com/game

:D

Just read what Shinanigans posted