I`m going with these atm (hopefully this thread creates more):
* Only use the paper map that comes with the pre-order, mark all the locations there instead of looking at the ingame map. Plan your routes, mark special encounters.
* Make rules for saving.
* Re-adjustment of sleeping rhytms atleast for the first week after 11th; when my wife`s asleep I`m playing Skyrim 8 hours in a row enjoying a harmony that resembles monastery of gaming. Sleep on short sections whenever I can`t fully concentrate into the game.
* Only play when there`s absolutely zero disturbing factors (kind of same as my previous one.

* Turn off all the communication methods, phone, msn, facebook and such.
* Only for PC to get the most out from the game; if you can`t max it on 1080p, now is the best time ever to upgrade your computer.
* Coffee, coffee and some more coffee.