There are people with hardware-specific technical issues. Bethesda should really have made sure the manual was linked in the Steam interface when it came out, but if you look again you'll find that it's there now. There should be an option to switch off mouse acceleration and make the sensitivity the same for the Y axis as it is for the X axis. Rebinding keys should work properly. The interface isn't brilliant, though if you can get used to it and use the keyboard controls it works fine. I've not encountered a single issue so far, though maybe I'm just lucky.
But... all these things will likely be patched soon, and assuming you've actually bought the game it'll just update through Steam. Who knows? Maybe they'll release a high-def texture pack too.
So basically: if you've not played it, stop attacking it. If you have paid for it, then go ahead.