1. Buy a big screen TV
2. Buy an Xbox controller
3. Hook Controller up to PC
4. Sit on couch and enjoy the greatest art masterpiece of our time
Seriously this is what I did and this game is amazing. I think it has surpassed just being a video game and could most definitely be considered an art masterpiece. I've played over 10 hours so far and have been to just ONE hold. And I'm not one of those people that picks flowers for hours. I've been doing all the quests around Whiterun.
I'm used to the PC controls though I do have that controller and might try it some time. Keep in mind some people are bugged and can't use the mouse in menus. (You CAN use the mouse in the menus, and it works fine for many players, it's just borked for some.)
I'm not a fan of the hotkey system, and the Xbox 360 controller won't fix that. I'll get used to it, but it's unintuitive. They should have let you save named sets of equipment in addition to the cumbersome favorites.