My advice would be, for now, go with the flow! Just use the best stuff you have for a while and see what you enjoy doing. That said, you are probably best off using a warrior type for your first playthrough. There is enough variety of weapons to give you some freedom with your build. Don't neglect non-combat skills. Being able to make basic potions is a valuable skill. All the crafting skills are actually useful. Remember though - levelling up non-combat skills helps you level up. So your enemies level up. MAKE SURE YOUR COMBAT SKILLS KEEP PACE.