Unlike Oblivion, which maintained a sense of immersion thanks to its eight-directional button hotkey option (which allowed for multiple weapon/spell/item change-outs without having to bring up immersion-killing menus), Skyrim's hotkey options are infuriatingly (to this gamer at least) ill-conceived. I understand they can't port over the exact same 8-hotkey directional button configuation from Oblivion, since Skyrim has the assigned-two-hands. Here's what I think is an elegant solution that would allow gamers to make multiple change-outs without having to constantly bring up a menu:
up D-button: same as now (brings up favorites menu)
left-up, left, left-down D buttons: 3 left hand hotkeys
right-up, right, right-down D buttons: 3 right hand hotkeys
down D-button: non-hand (potion/scroll) hotkey.
Bethesda... please patch! That Skyrim is so incredible only makes this oversight more maddening!