Yep. Why I put the "Flame Shield" thing, I'll never know.

Company of heroes with Shogun 2

WoW, Forskakan world

Splatterhouse 2 + Quest for Glory IV (self explanatory?)

The Immortal + Galaga (You fall into a hole and all of a sudden you're playing galaga?)

Rocket Knight Adventures + The Witcher (enough said)

Act Raiser 2 + Demon's Crest (2 Players at once, or both merged into one?)

Dragon's Revenge + Shinobi 3 (Shinobi is the pinball and you can use all of his moves and control him)

Warcraft 2 + Diablo 1 (leading groups of WC2 units into the catacombs?)

The Elder Scrolls + EarthBound (Should take TES into a present-day setting, since the EB games are set in the present)
The Elder Scrolls + The Sims (oh wait, perhaps The Sims Medieval is this already )
Super Mario Bros Crossover + Abobo's Big Adventure (8-bit NES nostalgia to the max! )

Tim (aka the Slipperman)

Republican debates + Mario Party.

Madden NFL + WarHammer 40,000: Dawn of War.

Fallout + Skyrim.
Bioshock + Skyrim
Bioshock + Fallout
Digimon + Pokemon
Call of Duty + Pokemon

Angry Bird + Minesweeper

She-Ra (or He-man) + Batman Akrham City: You play as a member of the Great Rebelian (and maybe in some parts you play as Adora and or She-Ra) fighting against Hordak's Army.

We call that Happy Tree Friends

http://www.gamesas.com/topic/1187331-wip-welcome-to-rapture/

Bioshock + Sims would be fun too, pre-war Rapture that is.

Nice, makes me wanna get Fallout on the PC just to try it out

Bejewled and Neverwinter Nights

Firefly, Serenity.

- open world(s) sandbox game using a gaming engine that supports a space simulator

- customizable ships.

- barter between worlds.

- reavers, 'nuff said.

- story written by Joss Whedon

Just. frigging. do. it!

I'm looking at you Todd Howard