I only hope that Bethesda will put additional time into development to get as many of the bugs out of the game as possible. Five years running and there are STILL patches being released for game-breaking bugs in Oblivion...and though I haven't played it yet, Skyrim is the same from what I've heard.
I have no doubt that Bethesda will make this a quality, fun-filled experience...I just hope they spend more time than usual fixing bugs, and/or allow for an extended beta test.