I've noticed no difference in performance between 1 screen or 3. I'm running with a single Radeon HD 5870
The only anomaly I've seen so far is the model for the players hands and weapon seem to be stretched horizontally, quite an odd bug, one i've never seen before. It's always been hud elements or menus, never actual 3d models that stretch. Regardless, it is still perfectly playable. Id' be nice if they fixed the weapon stretch in a patch though. We'll see if they bother with the 1% of us with a multi-mon setup.