To enable higher rez and or 3 monitors in Windows 7 (if hardware supports it)
go to your user folder then "my documents" then "my games" then "skyrim"
open skyrimprefs.ini
look for two lines "isize H= and isize W= change to what ever your screen will support .

I'm now using Eyeinfinity across 3 monitors to play Skyrim @ H 1024 W 3840 with only the UI issue (still working on that).

[ if you go back into your game options settings again, you then have to edit the .ini file again, so make sure all other setting are correct befor editing.]

bump.

Have you found a solution for the horribly stretched UI? It makes the game unplayable for me.

Yeah, when you say "no issues" does that include the menu system? Because if so, that would be great.

onething at a time, still working on the UI, but it is still playable, I just coudn't play on 1 monitor.

I am going to pick up my copy later this morning (after a few R L meetings) . This is all helpful, especially the part about changing options resetting the ini, thanks for that. I am going to try to run it at 5760 X 1200. I am not planing on using bezel correction so that should help.
One hint, when setting up Dragon Age to run at this resolution I had the exact same issue where the game graphics were fine but the UI was off screen and not viewable. I made it to a video cut scene and after the cut scene played for some reason all UI was in proper perspective and I could play at the 5760 X 1200 from then on. I never figured out why but I am guessing that the cut scene adjusted some arcane setting.
I have no idea if this will help anyone, just data but one never knows. Also I am running three identical monitors . I did just install the new NVIDIA beta drivers that have had some optimization for SKYRIM in SLI so that may also help.
I will post more when I get it installed and see what I see.

Looks like the UI size is based on a ratio to just the Width instead of the height or both. (stll working on it).