Ok, no texture popups while gaming unless u count the first few seconds after a map has been loaded.

vt_useCudaTranscode 2
vt_pageimagesizeuniquediffuseonly2 16384
vt_pageimagesizeuniquediffuseonly 16384
vt_pageimagesizeunique 8192
vt_pageimagesizevmtr 8192
vt_maxaniso 4
vt_maxPPF 8
vt_restart
image_anisotropy 4

Ingame on thre graphics menu, I use full settings on everything including AA. Notice that only the first two vt_pageimagesize are set to 16k.
Thats all thats really needed cuz those two are mainly responisble for texture popups. I can't see any difference in quality between the 8k textures and the 16k. For some reason the game fills up more memory with environment textures at the 16k mode than on the 8k one, hence the lesser popups. The other 2 vt_pageimagesize where I use lesser textures aren't the ones causing a problem so they are fine left in 8k mode or lower. I did however experience some weird lockups when combining 4k's with 16k's but I haven't tried it enough to rule out the fact that i might have been pure coincidence. There are more tweaks out there to get even sharper/crisper looking textures.

http://forums.steampowered.com/forums/showthread.php?t=2159167
http://donotargue.com/cfg-makers/rage/