I just noticed that my 2H skill was red and reduced from 40 to 25. There are no active effects listed. I tried a cure disease potion and got a blessing but neither worked. What could be going on and how can it be fixed? any ideas?

I keep hearing this come up. It's most likely a bug and seems to fix itself with time. Some have reported it fixing with the next skillup.

But just for a completely out of left field idea, when was the last time you ate?

You were right; as soon as I leveled it was fixed.