After taking the 3rd drink with Sam, the screen refuses to black out. I've reloaded, gone back to earlier saves, and rebooted my system. i was thinking it could be because of one of two things, or both. Ysolda is dead. I didn't kill her. I have no idea what happened. I got a note from a courier saying she had been killed back near the start of the game. Second, I married Senna, who is the priestess who wakes you up in the temple after you pass out. I'm pretty mad, regardless, if someone dying (which I played no part in), or me marrying someone will keep me from getting one of the Daedric Artifacts.