I have noticed a lot of people (including myself) have had the issue of when clicking start on skyrim it gets to the dragon logo and then crashes to desktop.
Now i use Nexus Mod Manager and my problem was having a corrupt mod file/files these were causing the game to crash to desktop.
Now for the long winded process of sorting this out, what i did was as follows....
Click the (Plugins) Tab in Nexus Mod Manager and make sure that ALL!! of your downloaded Mods that are in there are unticked, start the game and if it does not crash to desktop simply exit the game and then in Nexus Mod Manager click the first Mod which is under (Skyrim.esm) and then click play and see if the game loads up without crashing to desktop, if it doesn't repeat the process of ticking each Mod, then if the game does crash to desktop again then make sure you untick that last Mod as this will be the culprit thats causing it to crash, there maybe more corrupt Mods in your plugins so simply keep doing what i have told you until you have ruled out ALL!! corrupted Mods, then simply play the game and kill as many Imperial scum bags as you can.
I hope this helps if not message me on here and i will answer your queries.
Happy Gaming!