Open up the command prompt (~) and type coc and then the name of an area preferably a smaller area like Rorikstead.
Also I've read that save files become bloated after awhile and your game can become stable I've noticed this on my characters with 100 hours of game-play +.
The
Skyrim Crash Prevention and FPS Booster Mod on the Steam workshop may helpalong with Possessive Corpses no more lazy zombies and shy nirnroots - Possessive Corpses on the nexus (Which is being a tit at the moment so i cannot link).
That is all I can offer.