I'm playing the game uninstalled now, and after having played it installed for month's I notice little to no difference. Aside from the xbox being louder. Although my game has been freezing more lately, mostly during loading screens. That could be dawnguard or the new patch though.
Textures have always looked okay for the most part, recently I've had dragons appear low res which never happened for characters from months ago. The only time items look low res is sometimes an NPC's clothing is blurry and the preview shots of items in the inventory seem to randomly switch between low and high res.
For example; You can see what seem to be scrathes on items like the Iron Shield and Scaled Helmet when they are high res, but at times the texture of these items(and many others) downgrade where I can't see these features. If I drop the item and then pick it up usually the textrure fixes itself, for a bit. Eventually I see the texture of the item downgrade again and then fix itself whether I do something or not. This happen whether the game is installed or not, but usually the 'drop item' fix works better with the game uninstalled.
Again this only happens to items in the preview shot of it in the inventory, elsewhere they generally look fine. While anyone can comment, I would apprieciate if someone like Gstaff could explain why this is and will it ever be fixed.