Do those of you who use ENB mods leave Depth of Field turned on, or is that mostly used for screenshots? I admit it makes some very impressive screenshots, but it doesn't doesn't immediately focus on what I want it to. Maybe it just takes getting used to? How is it during combat?

Every ENB configuration handles DOF a bit differently, check out http://skyrim.nexusmods.com/mods/23765 for a particularly well implemented version.

That is the one I am using.

Do you leave Depth of Field on at all times?

No I had to turn off SSAO, DOF, and skylighting for performance reasons. I'd love to have kept it on though.

If you for whatever reason dont like the enb DOF, try this http://skyrim.nexusmods.com/mods/12525 i find it to be a lot more subtle than enb dof and a lot more customisable.

What do you get out of disabling all those features with ENB? Color enhancements?

http://skyrim.nexusmods.com/mods/13306 allows you to assign hotkeys and turn SSAO and DoF on and off easily whilst ingame. Ideal for playing without the effects running and then quickly turning them on for screenshots with a couple of key presses.

Best ENB Config i've seen is "seasons of skyrim" installed along with the "Climates of tamriel" mod. DOF is really good, isn't one of those which may cause headaches and such.

Perfect Shadows, Parallax and HDR with very little fps hit