We've seen in in The Thief, we even have it in WoW as Sap, and so on.
So, I think it would be a great addition to Skyrim or TES in general if we would be able to knock out some enemy while he is not aware of our presence. It is realistic and it would help greatly while playing, roleplaying like a thief.
So yeah, it wouldn't be a killing blow ofcourse, just knocking him out for good.
Any thoughts on this?