Maybe, if you're not used to put yourself in other people's heads, so to speach, then it might feel odd to play a character of the opposite six. How much work have you put into her backstory, personality and so on? These things help, you know

I focus more on the personality than the gender - I thought it would be odd to play a male character, but it turned out to be fun.
The again, if you've given it a try and don't like it, maybe it's just not your thing.