First off, I have the Xbox version of Skyrim, so I don't know anything about the Creation Kit. But last night, as I was making myself some chicken briasts for dinner, a thought popped into my head: What if there was salmonella in Skyrim? My character has eaten his fair share of raw chicken, as well as other meats, but nothing bad can possibly happen as the game exists. So what if there was a way to give raw foods a chance of infecting you with diseases? The effects of the diseases might be reduced stamina, damage output, speed, etc. My guess would be a scripted event, say a 1 in 5 chance of getting sick.

http://steamcommunity.com/sharedfiles/filedetails/?id=13056 incorporates food spoilage over time, and if you eat something spoiled, there is a chance you can get food poisoning.

I noticed enabling this feature results in a lot of Papyrus debug log error messages, however.