Places like Summerset Isle, Elsweyr, and Black Marsh etc are all being designed and mapped out for the *first time* by Zenimax Online, not gamesas. I'm talking building archetecture, map scale, terrain etc. To maintain continuity gamesas will have to take these design elements into account for any future single player games just as much as Zenimax Online had to take the design of ES 3, 4, and 5 into account for TESO, and they will not really be free to design these provinces as they might want.
Just as a disclaimer - I had always thought there would be an ESO, but I'd thought it would be set on Akavir for this very reason. Perhaps the single player games will move to Akavir instead?