I picked up Dishonored a few days after launch. Played fine at first, but the 2nd day of playing, windows would crash when I try to start the game up. I noticed in the blue screen it was calling out a driver for my marvell hard drive controller (mvs91xx.sys). I uninstalled that and went ahead and confirmed all my other drivers were up to date. I was able to start the game back up. I was able to get through the starting sequence just fine, but when it went to the loading screen to transition to the prison it crashed again. At 1st I thought it was just a lag spike, but then the blue screen comes up (not calling out any file names) and PC restarts.
Asus Rampage 3 Extreme MB
Core i7 970 @ 3.2GHz
12GB Ram
2 SLI Nvidia GeForce GTX 460's
OCZ 120GB SSD
Windows7