If they are following for a quest, probably. If they are actual followers, I don't think so.
I don't want Esbern or Delphine to become hostile towards me. I know they normally didn't when I was a werewolf on my raelly old save unless I used the fear shout on them.
My follower is a mule, I might need to buy an armoured troll though, they are great. I'm planning on introducing him to the Throat of the World mountain troll. Then take him through Blackreach.