I think I read somewhere that on a high chaos playthrough, people were unable to save the two scientists on 'The Loyalists.' On my high chaos game, however, i didn't notice any difference to their situation compared to my low chaos one. Did I miss something, or did I never even really read this in the first place?

I saved them on my high chaos game, too. But I think mine was "middle chaos" (despite what it said on my mission screens) since Samuel didn't rat me out on the final level.

Interesting, because Samuel DID rat me out on the last level on that playthrough.

I murdered pretty much everyone up to that point, and saw no difference in the scientists situation from my low chaos run. So I saved them, then murdered them.