Short version of the idea: Having time pass whilst in menus, with the SYSTEM menu being the only exception. The system menu would pause time so you could go and get a Coke or take a leak with the game paused so your character didn't die, but time would keep passing while in any other menus, so it would be largely impossible to spam potions, change armor and the like as a zero-time action in the middle of combat, and you'd be well advised to make sure your surroundings are safe before consulting your map or a book.
I asked if any such mod existed http://www.gamesas.com/topic/1396211-has-anybody-made-a-mod-where-most-menus-dont-pause-time/, but it doesn't sound like one does, and I got some people saying it doesn't sound likely that such is possible.
So here's the nut of it; can menus and pausing be separated? Is there a way to pause the game that would only allow you to enter the System menu, but prevent you entering other menus? Could those other menus be called up while time continued to pass?
I think with all the interest in hardcoe mode mods and the like that there might be some interest in my idea, which would force a degree of tactical thinking by removing the ability to spam potions, wear a set of sneak-enhancing clothing and then magically switch to full armor in zero seconds if spotted, forcing people to be aware of their surroundings and realize that they can't just glance around the map forever or re-read that book without checking their surroundings every so often, and so forth.