From the OP, it doesn't sound like mod recommendations were being asked for. Simply what the most common things to do were in case something breaks.
On topic, here's the rundown:
1) Make sure not to install Steam in the Program Files directory on the system's root drive. If you do, move Steam: https://support.steampowered.com/kb_article.php?ref=7418-YUBN-8129
2) Keep as little as possible running in the background
3) Turn off all auto-saves for Skyrim
4) Only save with the Esc menu and keep all of your saves in case something goes wrong. Here's my standard post on this:
Spoiler I go further than that. I pack my saves into archives of about 100 (give or take, it depends on how many I've got in similar locations near the 100 limit of mine; I do that to save more space with solid compression) saves a pop using the 7z archive format at maximum compression and the LZMA2 algorithm. Works like a charm.
5) Don't touch uGrids or do any memory "tweaks" you may read about, as those can cause problems
And now for common fixes:
1) Refresh the INI files by deleting the INI files in (My )Documents/(My )Games/Skyrim and running the Skyrim Launcher to regenerate them
2) Verify the files via Steam. Right click on Skyrim in the Steam Library screen and click properties and find the Verify Game Cache option somewhere in the window that pops up
3) Wait 31 in-game days in an isolated location
4) The nuclear option: go back to a previous save (part of why I suggested the save managing above) from before the issue occurred