None really bother me, The only thing that bothers me is the general public's lack of understanding of what a meme is. They seem to think they're only a picture with a brief joke as the punchline.
Definitely "Arrow in the knee". I can't accurately describe how I feel about it without getting myself permabanned. Contrarily, the Human Revolution-inspired "I never asked for this" meme http://static.fjcdn.com/pictures/I_85a2f0_2607182.jpg.