Initially the game worked fine, and I could travel to any location without incident, now when trying to enter certain areas like brandy-mug farm, the game crashes when I get within a certain radius, eg if I were to exit Windhelm after fast travelling there, the game would crash. Tried everything but nothing seems to work bar loading an old save game, it seems that as my time in game progresses the accessible areas decrease like the world is being swallowed by a black hole.

I'm running at maximum settings bar 4x AA, 1920x1080. Save file size is 9.2MB. Also running SKSE and an ENB amongst the other mods listed.

My Specs:

Intel 3570k @ 4.8GHz
8GB DDR3 1600 RAM
ATI Radeon 6950 2GB
Samsung 830 SSD 256GB

modlist

      	  	  ORIGINAL_VALUE	  22/01/2013 20:46:58        	  1.5	  Skyrim HD - 2K Textures - Skyrim HD v1_5 FULL - Dungeons	  <No Data>        	  1.5	  Skyrim HD - 2K Textures - Skyrim HD v1_5 FULL - Misc	  <No Data>        	  1.5	  Skyrim HD - 2K Textures - Skyrim HD v1_5 FULL - Landscape	  <No Data>        	  1.5	  Skyrim HD - 2K Textures - Skyrim HD v1_5 FULL - Towns	  <No Data>        	  1.5a	  Skyrim Flora Overhaul	  01/09/2012 20:29:13        	  1.5	  No More Blocky Faces - No_More_Blocky_Faces-1_50	  <No Data>        	  2.5	  Enhanced Blood Textures	  11/11/2012 20:37:22        	  2.12	  Better Dynamic Snow - Better Dynamic Snow v2-12	  <No Data>        	  8.0	  A Quality World Map - With Roads - Quality World Map - All Roads	  <No Data>        	  1.4c	  W.A.T.E.R. - Water And Terrain Enhancement Redux	  01/09/2012 20:29:13        	  3.1	  SkyUI	  22/01/2013 20:46:57        	  2.00	  Glowing Ore Veins 300 - Glowing Ore Veins 300 2_00	  <No Data>        	  4.5.0	  Deadly Dragons	  <No Data>        	  1.8.1	  Improved NPC Clothing - High Res	  11/11/2012 20:49:48        	  1.8.1	  Improved NPC Clothing - High Res	  11/11/2012 20:50:06        	  	  Linwe Armor First Person Fix - Linwes Arms	  20/11/2012 20:49:34        	  	  Ancient Nord Armor 1st Person Fix - Ancient Nord Armor Fix	  20/11/2012 20:53:08        	  0.6	  Blacksmithforge water fix - Blacksmithforge water fix - all languages	  20/11/2012 20:53:56        	  1.1	  Bowlegged jump animation Fix - bowlegged_jump_fix_11	  20/11/2012 20:54:29        	  v3	  Closer Quivers and Longer Arrows - Closer Quivers and Longer Arrows v3	  20/11/2012 20:56:00        	  4.0	  Fuz Ro D-oh - Silent Voice	  20/11/2012 20:57:01        	  3.0	  Hybrids Invincible Ebony Horse Armor for Skyrim	  20/11/2012 20:58:31        	  4.0	  Nitpick	  20/11/2012 20:59:10        	  1.1	  Trainer Gold Exploit Fix - TainerGoldExploitFix	  20/11/2012 20:59:58        	  1.2.3a	  Unofficial Skyrim Patch	  20/11/2012 21:01:38        	  2.1	  Project Reality - Climates Of Tamriel - Final Edition	  22/11/2012 16:52:36        	  2.0	  Better Beast Races v2 - Better_Beast_Races-2_00	  25/11/2012 15:45:51        	  6.BETA.2	  Immersive Armors - Immersive Armors v6	  25/11/2012 15:46:00        	  V1.1	  Better Circlets HQ V1o1 - Better Circlets HQ 2K V1o1	  25/11/2012 15:49:34        	  1.0	  Coverkhajiits - coverkhajiits female version	  25/11/2012 15:51:28        	  1.0	  Coverkhajiits - coverkhajiits male version	  25/11/2012 15:52:05        	  v2	  Dragon Glyphs HD - Dragon Smooth	  25/11/2012 15:58:21        	  1.13	  XCE - Xenius Character Enhancement - XCE-1_13	  25/11/2012 16:04:27        	  1.20	  Thats Ice	  25/11/2012 16:04:35        	  3.0	  HiRes Legible Road Signs - Hires Road Signs Version 3	  25/11/2012 16:08:42        	  1.0	  Possibly The Most Realistic Rocks and Mountains in Skyrim 8k 4k 2k and 1k Versions	  06/12/2012 19:31:28        	  1.0	  Benjamin318s Realistic Rocks and Mountains in Skyrim 8k 4k 2k and 1k Versions	  10/12/2012 14:22:54        	  1	  aMidianBorn Fur Armor	  10/12/2012 14:23:54        	  1.06	  Wet and Cold	  10/12/2012 14:36:40        	  1.2	  Better Dialogue Controls	  10/12/2012 14:43:48        	  1.1	  Immersive Weapons	  10/12/2012 14:47:06      

Skyrim.ini

[General]sLanguage=ENGLISHsIntroSequence=iLargeIntRefCount=999999uExterior Cell Buffer=36fFlickeringLightDistance=8192fMasterFilePreLoadMB=128.0000iPreloadSizeLimit=268435456uGridsToLoad=11uInterior Cell Buffer=72uExterior Cell Buffer=144[Display]fShadowLODMaxStartFade=1000.0fSpecularLODMaxStartFade=2000.0fLightLODMaxStartFade=3500.0iShadowMapResolutionPrimary=2048bAllowScreenshot=1fSunShadowUpdateTime=0fSunUpdateThreshold=2.0fDecalLifetime=750.0[Audio]fMusicDuckingSeconds=6.0fMusicUnDuckingSeconds=8.0fMenuModeFadeOutTime=3.0fMenuModeFadeInTime=1.0[Grass]bAllowCreateGrass=1bAllowLoadGrass=0[GeneralWarnings]SGeneralMasterMismatchWarning=One or more plugins could not find the correct versions of the master files they depend on. Errors may occur during load or game play. Check the "Warnings.txt" file for more information.[Archive]sResourceArchiveList=Skyrim - Misc.bsa, Skyrim - Shaders.bsa, Skyrim - Textures.bsa, Skyrim - Interface.bsa, Skyrim - Animations.bsa, Skyrim - Meshes.bsa, Skyrim - Sounds.bsasResourceArchiveList2=Skyrim - Voices.bsa, Skyrim - Voicesixtra.bsa[Combat]fMagnetismStrafeHeadingMult=0.0fMagnetismLookingMult=0.0f1PArrowTiltUpAngle=0.7f3PArrowTiltUpAngle=0.7f1PBoltTiltUpAngle=0.7f3PBoltTiltUpAngle=0.7[Papyrus]fPostLoadUpdateTimeMS=500.0bEnableLogging=0bEnableTrace=0bLoadDebugInformation=0iMaxAllocatedMemoryBytes=3000000000[Water]bReflectLODObjects=1bReflectLODLand=1bReflectSky=1bReflectLODTrees=1[Camera]fOverShoulderAddY=0.0fOverShoulderPosZ=10.0fOverShoulderPosX=0.0fOverShoulderCombatAddY=0.0fOverShoulderCombatPosZ=10.0fOverShoulderCombatPosX=0.0fOverShoulderHorseAddY=-72.0fOverShoulderHorsePosZ=50.0fOverShoulderHorsePosX=35.0fActorFadeOutLimit=-100fMouseWheelZoomSpeed=60.0f1st3rdSwitchDelay=0.95iHorseTransitionMillis=001 

Skrimprefs.ini

[General]fBrightLightColorB=1.0000fBrightLightColorG=1.0000fBrightLightColorR=1.0000iStoryManagerLoggingEvent=-1bEnableStoryManagerLogging=0[Imagespace]bDoDepthOfField=1iRadialBlurLevel=2[Display]iBlurDeferredShadowMask=1fInteriorShadowDistance=3000.0000fShadowDistance=2500.0000iShadowMapResolutionSecondary=1024iShadowMapResolutionPrimary=2048iShadowSplitCount=2iMaxAnisotropy=16fLeafAnimDampenDistEnd=4600.0000fLeafAnimDampenDistStart=3600.0000fTreesMidLODSwitchDist=3600.0000fGamma=0.9600fDecalLOD2=1500.0000fDecalLOD1=1000.0000fSpecularLODStartFade=1500.0000fShadowLODStartFade=200.0000fLightLODStartFade=3500.0000iTexMipMapMinimum=0iTexMipMapSkip=0iWaterMultiSamples=0iMultiSample=4iShadowMode=3bTreesReceiveShadows=1bDrawLandShadows=1bFull Screen=1iSize H=1080iSize W=1920fMeshLODFadePercentDefault=1.2000fMeshLODFadeBoundDefault=256.0000fMeshLODLevel2FadeTreeDistance=2048.0000fMeshLODLevel1FadeTreeDistance=2844.0000fMeshLODLevel2FadeDist=10000000.0000fMeshLODLevel1FadeDist=10000000.0000iScreenShotIndex=9bShadowMaskZPrepass=0bMainZPrepass=0iMaxSkinDecalsPerFrame=25iMaxDecalsPerFrame=100bFloatPointRenderTarget=1sD3DDevice="AMD Radeon HD 6900 Series"bFXAAEnabled=0iShadowMapResolution=1024fShadowBiasScale=0.3000iShadowMaskQuarter=4iAdapter=0iPresentInterval=1iShadowFilter=3bShadowsOnGrass=1bTransparencyMultisampling=0bDeferredShadows=1bDrawShadows=1[Grass]b30GrassVS=1fGrassStartFadeDistance=7000.0000fGrassMaxStartFadeDistance=28000.0000fGrassMinStartFadeDistance=0.0000bDrawShaderGrass=1uiMaxSkinnedTreesToRender=24[MAIN]bGamepadEnable=1bCrosshairEnabled=1fHUDOpacity=1.0000bSaveOnPause=1bSaveOnTravel=1bSaveOnWait=1bSaveOnRest=1fSkyCellRefFadeDistance=150000.0000[GamePlay]bShowFloatingQuestMarkers=1bShowQuestMarkers=1iDifficulty=4[Interface]bDialogueSubtitles=1bGeneralSubtitles=1fMouseCursorSpeed=1.0000bShowCompass=1[Controls]fGamepadHeadingSensitivity=1.0000fMouseHeadingSensitivity=0.0450bAlwaysRunByDefault=1bInvertYValues=0bGamePadRumble=1bMouseAcceleration=0bUseKinect=0[Particles]aiMaxDesired=750[SaveGame]fAutosaveEveryXMins=15.0000[AudioMenu]fAudioMasterVolume=0.3500fVal7=1.0000uID7=0fVal6=1.0000uID6=0fVal5=1.0000uID5=0fVal4=1.0000uID4=0fVal3=1.0000uID3=94881fVal2=0.4500uID2=466532fVal1=1.0000uID1=554685fVal0=0.8000uID0=1007612[Clouds]fCloudLevel2Distance=262144.0000fCloudLevel1Distance=32768.0000fCloudLevel0Distance=16384.0000fCloudNearFadeDistance=9000.0000[TerrainManager]fTreeLoadDistance=75000.0000fBlockMaximumDistance=250000.0000fBlockLevel1Distance=70000.0000fBlockLevel0Distance=35000.0000fSplitDistanceMult=1.5000bShowLODInEditor=0[NavMesh]fObstacleAlpha=0.5000fCoverSideHighAlpha=0.8000fCoverSideLowAlpha=0.6500fEdgeFullAlpha=1.0000fEdgeHighAlpha=0.7500fEdgeLowAlpha=0.5000fTriangleFullAlpha=0.7000fTriangleHighAlpha=0.3500fTriangleLowAlpha=0.2000fLedgeBoxHalfHeight=25.0000fEdgeDistFromVert=10.0000fEdgeThickness=10.0000fPointSize=2.5000[Trees]bRenderSkinnedTrees=1uiMaxSkinnedTreesToRender=20[Decals]uMaxDecals=1000bDecals=1bSkinnedDecals=1uMaxSkinDecals=100uMaxSkinDecalsPerActor=60[LOD]fLODFadeOutMultObjects=15.0000fLODFadeOutMultItems=15.0000fLODFadeOutMultActors=15.0000fLODFadeOutMultSkyCell=1.0000[Launcher]bEnableFileSelection=1bShowAllResolutions=1uLastAspectRatio=3[BlurShaderHDR]bDoHighDynamicRange=1[BlurShader]bUseBlurShader=0[Water]iWaterReflectHeight=1024iWaterReflectWidth=1024bUseWaterDisplacements=1bUseWaterRefractions=1bUseWaterReflections=1bUseWaterDepth=1 

"uGridsToLoad=11"

Seeing that, I recommend you completely wipe out your INI files and let the game regenerate them and not readding whatever changes you made to them. If that fails, uninstall all of your mods.

The problem was already occuring before the uGridsToLoad variable was modified and iirc saves created using a high value can't be loaded using a lower value. I can try removing the mods, but I'm not sure whether my save games will load afterwards.

Still, uGrids above 5 is a disaster waiting to happen.