I want to know who uses this and how often can it be useful and when. It just seems that NPCs have large reserves of magika and stamina that no poison or enchantment really matters. I am missing something or just using it correctly?

I never had. It's much better to inflict fire-frost-shock damage.

Never used that. I always opt for absorb magicka/health enchants.

I'm not sure what the advantage is to damaging it versus just absorbing it, like videogamemage said. That ability seems clearly superior to me....

Yeh, that has always confused me...seems that outside of paralysis, affects only work well against the player. I miss the poison style of games that focus less on damage and more on control, balancing the two. Would be so awesome to blind someone for 6 seconds to make them inaccurate

Nope. I only used it when it was for the quest.