I am really hoping this won't end up being a Generic Tabb Targeting WoW/EQ clone where you point and click and have no control over your melee weapon and simply press a command to attack. As for using magic, it should be played like how it was in Skyrim, similar to an FPS shooting Destruction spells at the enemy with no automatic lockon. Really,
http://www.mmorpg.com/discussion2.cfm/thread/397666/Target-based-combat-Really.html
There is already talk of this on other forums but is there any official word from Zenimax on what the gameplay will be like? I know this forum is bias and many people here worship Zenimax.