http://www.gamesas.com/index.php?/topic/1123313-attn-best-way-to-fix-quicksave-bug/
After playing for a few hours, I could NOT start up my game after trying out many different solutions found on the internet. When I launch up the game through steam, as soon as I push "Play" it will say that the game have stopped working and kicks me out.
It looks like steam cloud is messing up our save games and cause Fallout to crash right when we start the game.
1) What I did was use gtfagan's solution of removing yourself from permissions to the steam/userdata/xxx folder that Steam keeps your corrupt saves games.
Note: After doing this, you should get a "you don't have permission to view this folder" when you try to open stea/userdata/xxx folder.
2) Afterwards, goto your Documents/My Games/FalloutNV folder and backup your save games.
3) Note that the save game you want is probably named "xxx.fos.bak" (eg. autosave.fos.bak). Change this to autosave.fos
4) Delete the entire My Games/FalloutNV/ folder.
5) Copy your backup up saves back into My Games/FalloutNV/Saves/ folder
6) Play the game.
Note: Steam will tell you that it cannot sync their cloud data. This is because Steam will not be able to access the userdata folder and thus cannot corrupt your save games!