I know this topic has probably been beaten to death and normally I would not post such things, I would just deal with it. I mean I have so since I bought the game. No problem. However there are bugs that are halting my enjoyment of the game. 1 in particular that is really becoming a nuisance. The other is simply I cannot finish it for some reason.
Let me list them here and while I am at it perhaps I can list a few more as I remember them.
Hope this helps and it is non critical and instead informative and helpful to the developer.

By the way, this is one heck of a game. I cant stop p[laying it, even with the few side steps. Congratulations. I whole heartedly recommend this to all my buddies.

My biggies issue right now is that Ed-E some how glitched. I was on a mission where you have to detonate some gas and escape the impending explosion before it roasts you. I did it, but I think Ed got caught in the blast. Not really an issue since the NPC just go unconscious. However, I left the area so on, but no Ed-E I thought he was perished or something. I went to look for him at his home base and he was not there. I looked at my perks and there was the perk as if he has never left me AND others acknowledge him as if he was still with me.
So the issue is I cannot access him, I cant talk to him, I have the perk but I cant get my stuff that he was holding either, plus there are places I cannot enter i.e talk tot Caesar or Mr. House because supposedly he is with me and this is stopping me from continuing my game.

Smaller issues.
There are missions I have completed that do not register as being completed and the radio announcer does not register the deeds as being done, I did received the experience for them.
For example the Powder Gangers in jail. I helped over take it back, still the NCR are moving around like nothing has happened.
The Van Graffs wanted to see Cassidy, however I went the NCR route, the mission still appears on my list as "please bring her (Cassidy) to see us.
The sixbot to the Wrangler, Ive been ALL over the the area where the map says to go and nothing, also Ralph tells me where it may be and it cant possibly be where he says. There is nothing back there.


Well that's it.

In all my 32+ hours. These are all the issues I have experienced.
The Ed-E one is the worst because is actually stopping me from playing. Also you may want to pop a warning to players that if for some reason a npc needs to leave you as Ed-E does in some part of the game, whatever was in his inventory is also gone. Cause I lost A LOT of stuff.

Thank you and I hope this can be addressed soon, until then I have to just save my game at the entrance to Caesar hut and pray for the best.