So I've found that when I disabled all the auto save features. That I'm able to play for a few hours before I need to exit and re-enter the game but to lag. Figured I'd share.

PS. Save file size 12 MB

Nice suggestion.
Im not as far on any char to experiance this lagg/framerate issue.
But once i'll get there, this could be useful to try out.

It's also a pain in the butt, has you no longer have that 15 min autosave/fast travel, etc save point. But then again who doesn't play a bethesda game and have multiple save files (from fear of file corruption alone) ?!