I'm not sure how to divide my skills, I will favor guns, repair, lockpick and some more. Should I max one of these first or divide them more even on lvl up? Is about 80 enough on skills? Also is it needed to have high science if I go for high lockpicking? Thanks for any tips.
You can hardly go wrong with concentrating on guns, locksmith, and repair. (Probably the three most important you could choose, other than, maybe, sneak.)
Locksmith will definitely get you around lack of science skill, in almost all cases. The instances it don’t, is not “game-breaking”.
I normally (unless there’s a certain perk requirement I’m shooting for) go with dividing my available skill points by 4. Take that result and apply it to your “3 main” and split the remainder amongst the “other” skills you find interesting. Of course that’s not a “hard and fast” rule. If it takes an extra point or two to raise my sneak or repair (or whatever I’m shooting for) to an even “0” then I usually go for it.
At some point you’ll start looking at the skills you’ve neglected, and maybe wishing you’d invested a little more heavily in other skills. But in the end it’s a moot point. The game can be beat with just about any combination of preferred skills. It all depends on your preferences and style of play.