Autosaves can get corrupted over time as they are overwritten so many times. Also, cells are rendering when most autosaves are created and this can cause issues with the saves. Not all people have this problem, however it is common enough on all platforms that we do not reccomend anyone rely on Autosaves and instead use a series of manual save slots. You can cycle through them, but just don't keep using the same one over and over. In fact, it may be best to turn the feature off so you don't get in the habit of relying on them.
Quicksaves, as on the PC, are not complete saves and can cause issues with mods. This usually results when changing mods more so than just using them. However, some mod based scripts are not happy with Quicksaves. While it is nice to use Quicksave, do not rely on them either. Use Quicksave along with Manual Saves and always make a manual save before you leave the game.