To start things on a positive tone, I am utterly disappointed I spent my money on this. I loved Fallout 3 and love this until this happened.
Now I think this sequel is G A R B A G E!
How can you release content that busts saves?! I understand glitches but saves? How come your programmers aren't sacked yet?
So I have been playing for a week now, got to Vault 22 and did some quests, finished, went out and quick travelled, then for some reason I loaded a quick save, and voila, game crash. Upon trying to load any other save the game keeps crashing.
Reinstalled everything, copy/paste save from a backup location on my HDD, loads at first, subsequent saves crash, and so on.

I hope you understand how this can be a game wrecking experience, utterly frustrating especially when I spend money for a piece of J U N K!
This has been happening for quite some time and I'm very disgruntled for the fact that this hasn't been hotfixed already.
There goes Bethesda/Obsidian rep.
*sigh*

EDIT: Oh, and just for the record, I will NEVER buy a Bethesda game again. EVER.

Try avoiding that vault or single the problem to exact moment in the vault. I had the same problem in come fly with me quest, playing with all possible possibilities halped me get past that mess. But i have to yet come to vault 22, so i dunno for sure what's going on there

Well, the problem is that I'm inside the the vault already and I have no previous saves, I've had no problem until this whatsoever.
I will definately not start over.