Hi there ^_^ My fiancee and I are both having fun playing New Vegas, however we've run into a few problems and searching this forum/Google hasn't turned up any results.

The first thing that happened was, I couldn't fire my weapon - This mysteriously solved itself with a restart so I thought nothing of it and haven't experienced it since. My fiancee (playing on a different computer) experienced something similar, except he couldn't draw his weapon, or access the Pip-Boy - Restarting hasn't solved this issue, and he still can't play.

If anybody has come across a solution to this problem, we'd both be really grateful!

I have come across this on occasion during VATS or during bullet time (a mod from the new vegas nexus). Unequipping and re-equipping the weapon resets it most of the time for me.
I *think* that cinematic kills may be causing it too.. seems to have more to do with the time speed variance than anything else I've stumbled over.

Edit: try this.. enter VATS again or use your bullet time trigger on whatever is nearby, then exit it. then try to fire/reload/switch weapons/loot, or whatever you were doing.

Hope it helps.