I just wonders how peoples are using crossfire for this game when no crossfire profile exist for this game.
Enabling/disabling and using crossfire are 2 different things. I can enable and disable it, but it doesn't mean it's working for FNV (Lack of profile as you mention.) just that the cards are set to use crossfire if a game does have a profile.
OP:
I tried both disabled and enable and it was the same FPS in both.