So after 300ish hours of play, I've come across something entirely new. My current character has bugged out. Whenever I have the pipboy opened and I press a hotkey (1, 3-8), the game CTDs. This happens every single time. I loaded a different character, and everything works fine. Did my save get corrupted somehow? Is it fixable?

Yes, there is a workaround:

http://www.gamesas.com/index.php?/topic/1136139-ctd-on-hotkey-assign-fix/

Thanks, that worked! Cheers!