Hey Cyberjelly, I don't know the cause of this or how to stop it permanently, but I know a temporary fix that I learned about when playing Fallout 3.
Start up your game, go to options and disable save on rest,travel,etc., then afterwords go get killed (You may blow yourself up, have someone shoot you, it doesn't matter.). After you die it will load your previous autosave/save/whatever and you may enable saving again.
However, the game still randomly crashes for me and every time I start the game up I have to do this, but it's the only fix I know of.