Given the look of the rusted out vehicles in the game and the little aircraft i've seen in the FO universe, I'd love a chance to do a flight sim.
*spoiler*
Well you can get the Boomers their Bomber and they -do- a bombing run on Hoover Dam... simulators would be awesome as would in game bombing runs with the Boomers.
Boomer: Oh my God!
You: Look at all those Deathclaws just North of Nellis
Boomer: What the hell do we do?
You: Nuke them from orbit. Its the only choice!