I'm having the exact same problem. Basically, after I load a save-game, I can sometimes press tab to open the pip-boy menu and navigate around if I'm lucky. However when I change and equip a weapon and then close, the menu freezes. I can't see my weapon at all or fire it, I can't press tab to access the pip-boy menu, I can't press the Esc-key to access the main menu. The only thing I can do is jump and walk around (and quick-save by pressing F5?, quick-load doesn't work either). As such the game is completely unplayable, I can't do anything at all... I've updated the game with the latest patch and the Dead Money DLC, but it didn't fix the problem.
Has anyone else had a similar problem?
- Xm8