» Fri May 27, 2011 8:26 pm
I would make a fresh save before doing that, as applying negative shifts to skill or SPECIAL values can crash the game.
I would also recommend making said save right after using an auto-save point (such as a zone door), as there's a chance, albeit fairly low, of said crash totaling the save in the process (I had this happen in FO3 during a test, fortunately I had just left Megaton).