What's the method you favor?
My current favorite is 160 North from Goodsprings. You'll want one or two stealth boys (graciously provided by the game via Joe Cobb's corpse and the school house safe) and a moderately strong weapon; some mines or powder charges help as well. I'm usually level 3, here.
Head west and up into the hills from Goodsprings. Go North, carefully following the ridge line until you are above Chance's Grave. Activate a stealth Boy; grab the Knife from the grave and sneak across the small canyon. There will be Cazadors to the right and left. Go straight and clamber up on the cliff face and go left. Stay as high as you can as the cliff veers to the east. You will find yourself above Bonnie Springs in a perfect sniping position. Lay down some mines on the paths to your position. Then start killing raiders. It's a tough fight but you'll get a Trail Carbine, Combat armor, a unique set of Knuckles (Love and Hate) and other good stuff.
Now, carefully head North on the west side of 160, watching for Bighorners and Fire Geckos. When you see Violet's camp angle East. VERY carefully sneak past this and Driver Nephi's hangout (unless you are up for some combat, like I was the last time I did this), shooting for the Samson rock crushing plant.
Now just run for Mccarren or straight to Westside.
I like this method because it's pretty suspenseful and there is very good loot.
