Here are my observations & ramblings after a good bit of playtime on Hard setting...

1. You make good use of most skills. This is plus compared to Fallout 3.
2. I swear some things must have been patched away ( red rubber balls ...)
3. Lockpick seems more important than hacking, must have for experience.
4. Unarmed needs nerfed, it seems way too powerful ( even on hard )
5. Tried energy weapons, wasn't that impressed. ( VATS use only?) I've seen some cool energy weapons later in the game, so I may give this a go again...
6. Non-VATS sniping is fun, fun, fun!
7. Content rich compared to Fallout 3, but map feels a lot smaller.
8. Playing through a few times, I always find little things I've missed before..that's nice.
9. I haven't picked up a sidekick yet, never was into sidekicks...maybe I'm missing some fun stuff here?
10. Still getting random crashes, last night was probably the worst yet..make a habit of quick saving!
11. Good game would buy again, considering the $/hours of enjoyment.