Level up both melee and unarmed because perks require both.
Finish Ranger Andy's quest to get Ranger Takedown move.
STR 9. (+dmg)
END 9.(you're going to take a lot of damage)
AGI 7+ (perks)
Yeah, this is good advice. Perks you will want: Super Slam, Stonewall, Piercing Strike, Paralyzing Palm, Slayer. Also, you need as much DR/DT as you can get, so medium/heavy armour building up to Power Armour is the way to go. Oh, and keep some explosives on you to level the playing field when outnumbered, and don't be afraid to use chems. My unarmed chars have always wound up massive chem fiends, Med-X, Psycho and Slasher are your friends.
Get used to the fact you won't be good at much beyond smashing heads, though; an unarmed/melee build is unlikely to have high INT and you need to do up two combat skills simultaneously, with what few skill points you have left over being best spent in Survival, Medicine or Sneak. It's pretty difficult to have a melee/unarmed specialist who's a jack of all trades, or so I've found.