Does anyone know if there are any quests similar to 'Tranquility Lane' as seen in FO3? I enjoyed the uniqueness of the quest, it was a little refreshing from the post apocalyptic world. I'm hoping that New Vegas might have something a little similar thrown in the game?

You asking for a spolier...?

Well, if there is a quest I don't need to know the outcome of it... but if a spoiler is necessary I don't mind I'm close to beating the main quest but I'm holding off so I can explore a bit more and finish up side quests. I was just hoping there might be something similar to the experience I got from Tranquility Lane

The Wiki is your friend
When in doubt, ask the Wiki
http://fallout.wikia.com/wiki/Fallout:_New_Vegas_quests

So a simulation device?
Nope.
Not as far as I know.
There are those chairs that were used for tranquility lane at two places but none of them are useable.

Currently there are no dream sequence/simulation quests where you're transported back before the war, no. Maybe there will be a DLC with House having you perform a pre-war simulation of New Vegas because he can't calculate the odds of something happening for some reason himself, he needs a human to figure it out so if it were to happen present time, he'd know how to deal with it. As a nice "salt in the wound" in-joke/self deprecating comment, House could say he can't complete the simulation himself as he keeps freezing and needing to reboot (imagine the angry frenzy on the boards THAT would set off).

Not that I know of but I bet a future DLC will have one seeing as the Boomers and BoS have a set up alot like Vault 112 or the Outcast set up.